Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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08.07.2010 |
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Introducing dimethyl-nandrolone
Dimethyl nandrolone's full name is 7-alpha,11-beta-19-nortestosterone. We call it a porcupine steroid: the extra methyl groups on the nandrolone skeleton make dimethyl-nandrolone interact more strongly with the androgen receptor than nandrolone.
The researchers mixed this steroid with their rats' food for seven days. They used dimethyl-nandrolone [DMA] in total doses of 0.4, 1.6 or 6.4 milligrams. They also used the ester analogue [DMAU] in total doses of 0.63, 2.5 or 10 milligrams. A control group was given methyl-testosterone in total doses of 1.0, 4.0 or 16 mg.
The figure below shows the effects on the rats' sphincter muscle, a marker for the anabolic effect of steroids.
The ratio of anabolic/androgenic effects of the new steroid is better than that of methyl-testosterone.
The figure below shows the effect of the doses mentioned above on the circumference of the prostate. The growth of the prostate is a marker for the undesirable androgenic effect of steroids.
Dimethyl-nandrolone is a powerful progestogen, the researchers discovered when they mixed the bare and the ester androgen with cells that had been modified with a progesterone receptor, and then looked at how hard the molecular progesterone machinery went to work in the cells' genome.
The researchers also looked at dimethyl-nandrolone's close relative 5-alpha-dihydro-dimethyl-nandrolone and commented: "It is interesting to note that synthetic 5-alpha-dihydro-DMA demonstrated androgenic and progestational potencies comparable to those of DMA in our in vitro assays."
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