Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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16.12.2017 |
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How hispolon helps the immune system to kill cancer cells
Hispolon, a phenol found in the medicinal mushroom Phellinus linteus, is not just of interest to ergonauts who want to optimise their hormone balance for the sake of their athletic performance. The findings of a Korean in-vitro study, published in Oncology Reports in 2016, suggest that hispolon may also help the immune system to clear up cancer cells. And if hispolon is indeed capable of doing this, then there are many more naturally occurring substances that can do the same...
Study
Results
Hispolon enhanced the production of Death Receptors 4 and 5 in the gut cancer cells, which in turn were activated by TRAIL. It seems that the phenol increases the sensitivity of gut cancer cells to TRAIL in this way.
The Koreans repeated their experiments with other kinds of cancer cells and observed that hispolon increased the production of Death Receptors for these too.
Mechanism
"CAAT enhancer binding protein homologous protein [CHOP] is also known to be a regulator of the death receptor via binding of CHOP to the death receptor promoter. We found that CHOP was upregulated by hispolon in HCT-116 cells and that hispolon can induce the death receptor through a CHOP mediated mechanism."
"We also found that hispolon-induced Death Receptor 5 was related to ERK activation, but independent of Jun N-terminal Kinases [JNK]."
"Another mechanism, induction of apoptosis through p53 was also investigated because of the importance of this pathway in the response to cell stress such as chemotherapy and radiotherapy. In this pathway, the upregulation of p53 is essential for an apoptosis event, however, hispolon could not induce p53 in HCT-116 cells."
Conclusion
Wild speculation on our part
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