Supplement with vitamin E supports the non-alcoholic fatty liver

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28.11.2023

Supplementation with a hefty dose of vitamin E improves liver health in non-alcoholic fatty liver disease. This is evident from a Greek meta-study, which was published in Nutrients in August 2023.

Supplementation with a hefty dose of vitamin E improves liver health in non-alcoholic fatty liver disease. This is evident from a Greek meta-study, which was published in Nutrients in August 2023.

Study

Greek epidemiologists, affiliated with the National and Kapodistrian University of Athens, collected 12 previously published trials in which liver doctors treated patients with fatty liver - with Non-Alcoholic Fatty Liver Disease, to be precise - with vitamin E.

The doctors then determined the effect of the supplementation based on the concentrations of ALT and AST in the blood of their test subjects. The higher the concentration, the more serious the liver disease.

The dose was 400 IU vitamin E per day or higher. 400 IU vitamin E amounts to 267 milligrams per day. More information about the dosage and forms of vitamin E used can be found in the table below. Click on it for a larger version.

Results

Vitamin E supplementation reduced the concentration of ALT and AST in the blood by approximately 7 and 5 points, respectively.

In some studies, researchers studied the effect of vitamin E supplementation in conjunction with an improvement in lifestyle. As you can see, vitamin E lowered liver values both in combination with an improvement in lifestyle and without lifestyle modification.

Click on the figures below for a larger version.

Conclusion
"Further clinical trials of higher internal validity investigating the optimal dose, the synthetic form of the vitamin, and the duration of therapy together with recording potential adverse effects are needed", write the researchers.

Source:
Nutrients. 2023 Aug 25;15(17):3733.

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