Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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11.01.2020 |
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NEP28, a SARM for your brain (and your muscles, of course)
Muscles
The Japanese did the same experiments with the androgenic testosterone metabolite DHT and methyltestosterone [MT]. They administered the substances with an osmotic pump, which they had implanted in their test animals.
NEP28 had an anabolic effect that, when administered at somewhat higher doses, was close to that of DHT and methyl testosterone. NEP28, on the other hand, hardly had any androgenic effects.
Brain
In multiple forms of dementia, doctors find these accumulations in the brain, and so pharmacologists study drugs that break down amyloid beta - hoping that these drugs can slow down or prevent neurological aging.
In mice, DHT, methyl testosterone and NEP28 did exactly what they were supposed to do. These agents activated neprilysin and, as you see below, degraded the amyloid-beta plaques. Of course, this does not prove that NEP28 actually combats dementia.
Click on the figure below for a larger version.
Conclusion
"SARMs having activity in brain are capable of improving various symptoms, including osteoporosis, sarcopenia, and neural diseases or cognition such as Alzheimer's disease simultaneously. Such children or SARMs certainly contribute to the enhancement of quality of life for many patients."
Critical comment
The dose required for a significant anabolic effect is very high. The human equivalent of the highest dose of NEP28 that the Japanese gave to their lab animals amounts to 250-300 milligrams per day...
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