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30.03.2023

Resveratrol helps type 2 diabetics lower glucose levels

Supplementation with substantial, but not excessively high, doses of resveratrol lowers glucose levels in people with type 2 diabetes. This is the conclusion of a Chinese meta-study, which appeared in Nutrition & Metabolism in 2017.

Study
Chinese endocrinologists, affiliated with Southeast University, traced 9 previously published trials in which subjects with type 2 diabetes had received resveratrol. The researchers aggregated the trials' results and analyzed them again.

In the trials, subjects received 10-3000 milligrams of resveratrol daily for 1-12 months.

More details about the trials can be found in the table below. Click on it for a readable version.

Resveratrol mimics the effects of caloric restriction at the cellular and molecular level. The plant substance activates enzymes that repair cells and increase insulin sensitivity.

Results
Resveratrol supplementation reduced HOMA-IR. That is, insulin sensitivity increased. Click on the tables below for a larger version.

Not all trials in which higher doses were administered were conclusive on their own. If you look at the table at the top of the page, you will see that researchers in those less conclusive studies had used doses of 1 gram of resveratrol or more.

Apparently the optimal doses are between 100 and 1000 milligrams per day. Then we are talking about supplements that contain only resveratrol; not about resveratrol-phospholipid complex supplements. The bioavailability of these complexes is exponentially better than that of regular resveratrol products.

Conclusion
"This study provides novel insights into the beneficial effects of resveratrol supplementation on type-2 diabetes," the researchers write.

"Specifically, resveratrol supplementation may improve fasting plasma glucose, HOMA-IR, and insulin in diabetic patients."

"The long-term risks and benefits of resveratrol supplementation are unknown. Understanding the efficacy of resveratrol in diabetic patients requires large-scale, well-designed, and population-based studies in the future."

Source:
Nutr Metab (Lond). 2017 Sep 22;14:60.

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Archives:
Insulin & Glucose Metabolism
Resveratrol

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