Aging without wrinkles due to vitamin C supplementation
According to Korean researchers, there may be a simple strategy that can help prevent the formation of wrinkles later in life - or at least delay the appearance of wrinkles. You only have to take 400 to 1600 milligrams of vitamin C every day. In SKH-1 mice this strategy seems to work.
The researchers at Yonsei University gave young mice an oral dose of 0, 50 or 200 milligrams of vitamin C per kilo body weight every day for 24 weeks. The human equivalent of these doses is approximately 0, 400 or 1600 milligrams of vitamin C per day. When that period was over - the mice were middle aged by then - the Koreans compared the skin of the mice with that of young specimens.
The Koreans experimented with hairless SKH-1 mice. As these mice age, their skin wrinkles. The cosmetic industry likes to use this type of mouse for research into new agents that must delay, stop or even reverse skin aging.
Supplementation with the high dose of vitamin C made the skin of the middle-aged mice [MA] look like the skin of the young mice. Supplementation with the less high dose of vitamin C was not that effective, but still delayed skin aging.
Vitamin C supplementation inhibited the increase in the total number of wrinkles, their length and depth, the figure above tells. Click on it for a larger version.
In the middle aged mice's skin cells, vitamin C inhibited the increase in the activity of the enzyme senescence-associated beta-galactosidase. This activity is a marker for cell aging. The more active the enzyme, the more aged and senescent cells are.
Supplementation with vitamin C reduced inflammatory responses and prevented the decrease of the amount of the amino acid hydroxyproline in the skin of the middle aged mice. As a result, the skin of middle aged mice was not thinner than the skin of younger animals.
"Overall, vitamin C [...] has the potential to be an effective antagonist to natural aging in skin", the Koreans summarize their findings.
The researchers were paid by the Korean pharmaceutical company Kwang Dong Pharmaceutical. Kwang Dong produces health drinks, cosmetics and supplements, among other things. The product shown below comes from the Kwang Dong Pharmaceutical factories.
Food Sci Biotechnol. 2018 Nov 22;27(2):555-64.
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