What kind of anabolic steroid was 2-alpha-methyl-nandrolone?
Years ago, in a 1955 patent by the American Upjohn, we discovered a curious group of anabolic steroids with a nandrolone skeleton and a 2-alpha-methyl group. [US Patent 2,989,549.] We initially thought that after publication of that patent, no one had taken a serious look at 2-alpha-methyl-nandrolone analogues. When we came across a Japanese study from the early 1960s, we realized that things were different.
Surfing the web, we came across an article that researchers at the Japanese pharmaceutical company Dainippon Pharmaceutical published in 1964. That article describes, among other things, a series of animal experiments with a series of anabolic steroids that are also described in Upjohn's 1955 patent.
The Japanese tested their steroid hormones on neutered male lab rats by injecting them for 7 days. Afterwards, the researchers measured the weight of the levator ani sphincter muscle to estimate the anabolic effect of the synthetic hormones. To get an idea of the androgenic side effects, they also measured the animals' prostate weight.
The anabolic effect of the 2-alpha-methyl-nandrolone analogues was less than that of testosterone, but their androgenic effect was much less. The ratio of anabolic-androgenic effect [the therapeutic index] was therefore a factor of 3-5 more favorable than that of testosterone.
The structure of many of the substances above is reminiscent of that of methasterone, a designer steroid that hit the market in 2005 as Superdrol. Methasterone, the structural formula of which you can see on the right, is a toxic steroid that can damage the liver and kidneys.
Methasterone, however, is not based on nandrolone, but on DHT. Despite this difference, we suspect that the list above contains quite a few steroids that are quite harmful to the liver. Based on what we know about C17 alkylated nandrolones, they may be even more liver toxic than methasterone.
One steroid for which that may not be the case is steroid 5827 or 2-alpha-methyl-nandrolone. You can see the structural formula at the top of the page. This steroid is probably not only mild on the liver, but may also be milder in androgenic side effects than nandrolone.
More side effects?
The Japanese also determined the estrogenic and progestogen effect of their steroids. It was nothing. That is in accordance with the content of Upjohn's patent.
Jpn J Pharmacol. 1964 Jun;14:138-49.
Liver damage & designer steroids: blame the manufacturer again 18.08.2013
More damaged livers from methasterone and madol 14.03.2009