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12.09.2016


These supplements contain methylsynephrine

Methylsynephrine is not a naturally occurring substance, but a medicine that the pharmaceutical industry has now rejected because it was too risky. The substance is found in a number of slimming supplements sometimes in higher concentrations than the pharmaceutical industry ever dared use for their products, writes American researcher Pieter Cohen in Drug Testing and Analysis.

Methylsynephrine
Methylsynephrine is also called oxilofrine or para-hydroxylephedrine. It's a synthetic compound, developed in the 1930s by German chemists as a stimulant. The chemical was available in some countries as a medicine against high blood pressure, in products usually containing 16-40 mg methylsynephrine.

Methylsynephrine is not a naturally occurring substance, but a medicine that the pharmaceutical industry has now rejected because it was too risky. The substance is found in a number of slimming supplements  sometimes in higher concentrations than the pharmaceutical industry ever dared use for their products, writes American researcher Pieter Cohen in Drug Testing and Analysis.
Legitimate pharmaceutical companies no longer produce methylsynephrine. The risk of side effects such as high blood pressure, stroke, raised heartbeat, sleep disturbances and psychological problems is too high. Methylsynephrine is on the doping list.

In supplements
If the pharmaceutical industry drops a substance that has been found to be too dangerous, then you can guarantee that a supplements manufacturer somewhere will start putting the same substance in capsules and powders, even if it's a compound not found in nature. And that has happened with methylsynephrine too.

Study

Cohen bought 27 different supplements that were labelled as containing methylsynephrine, and measured the amount of the stuff that the products contained. Nearly all of them were slimming supplements.


Supplement

Dosage on label (per capsule)

Dosage found (at max recommended dosage)

HyperDrive 3.0 (ALRI)

None

250 milligram methylsynefrine (4 capsules)

Shredder (Total Body Nutrition)

None

220 milligram methylsynefrine (3 capsules)

Fastin (Hi-Tech Pharmaceuticals)

None

190 milligram methylsynefrine (4 capsules)

Lean Pills (Line One Nutrition

None

98 milligram methylsynefrine (3 capsules)

Tummy Tuck (Total Body Nutrition)

None

44 milligram methylsynephrine (3 capsules)

Methyl Drive (Advanced Nutrition Systems)

None

35 milligram methylsynephrine (1 capsule)

Drop Factor (MTS Nutrition)

None

33 milligram methylsynephrine (2 capsules)

Exile (American Muscle Sports Nutrition Company

None

25 milligram methylsynephrine (3 capsules)

China White 25 Ephedra (Cloma Pharma Laboratories

None

23 milligram methylsynephrine (2 capsules)

Phenadrine (APS)

None

11 milligram methylsynephrine (3 capsules)

Hypercor (Kat-A-Lyst Nutraceuticals)

None

1.2 milligram methylsynephrine (2 capsules)

MethylDrene 25 Ephedra Elite Stack (Cloma Pharma Laboratories)

20 microgram methylsynephrine

0.05 milligram methylsynephrine (2 capsules)

Miami Lean (Skyline Nutrition)

10 milligram methylsynephrine

0.03 milligram methylsynephrine (2 capsules)

Eliminator X (RokHardBody Sports Nutrition)

None

0.003 milligram methylsynephrine (1 capsule)

Ultimate Burn (Schwartz Laboratories)

25 milligram methylsynephrine

Zero (2 capsules)

Matrix-Xtreme (One Body Nutrition)

8 milligram methylsynephrine

Zero (3 capsules)

Ephedra X (Xcel Sports Nutrition

None

Zero (2 capsules)

FireStorm (GE Pharma)

None

Zero (2 capsules)

Incineration (EN Enraged Nutrition)

None

Zero (2 capsules)

Burn2 (M4 Nutrition Companies)

None

Zero (2 capsules)

MethylDrene 25 Ephedra ECA Stack (with cayenne and ginger) (Cloma Pharma Laboratories)

None

Zero (2 capsules)

Burn (Pinnacle Sports Nutrition)

None

Zero (2 capsules)

RX 90 (MuscleSport Nutrition

None

Zero (2 capsules)

ThermoBombs (NutraClipse Premier Sports Supplements)

None

Zero (2 capsules)

Nciner 8 (Twisted Genetix)

None

Zero (2 capsules)

Ultra Fire (Live 4 Life Health)

None

Zero (2 capsules)

Burn-FX (Tokkyo Nutrition)

None

Zero (2 capsules)



Let's recap
Five supplements (HyperDrive, Shredder, Fastin, Lean Pills en Tummy Tuck) contained higher doses of methylsynephrine than the pharmaceutical industry deemed acceptable when methylsynephrine was still on the market as a medicine.

Almost half of all the supplements contained not a trace of methylsynephrine.

It was also striking that, for the few products that declared the amount of methylsynephrine on the label, the amount was not correct. In all these cases the substance was either not present or only there in minute quantities.

Cohen's discoveries are worrying to say the least. You can guess how the supplements industry has reacted to his findings.


These supplements contain methylsynephrine



If all the scoundrels working in the supplements industry lived in Gotham City, then Bruce Wayne wouldn't don a rubber suit at night but a white lab overall. And he wouldn't call himself Batman either, but Pieter Cohen.

Source:
Drug Test Anal. 2016 Apr 7. doi: 10.1002/dta.1976. [Epub ahead of print].

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