Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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11.03.2014 |
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Raloxifene: anti-oestrogen that boosts lean body mass and reduces fat
Tamoxifen, an effective anti-oestrogen that's popular among doping users, has a drawback. For women at least, in the longer term, its use reduces lean body mass and leads to an increase in fat mass. Another anti-oestrogen, raloxifene [structural formula on the right], does not have these disadvantages. A Dutch study suggests that it actually improves body composition.
Anti-oestrogens & body composition
Tamoxifen boosts these women's chances of survival considerably, and reduces the chance of estradiol-sensitive forms of breast cancer returning. That's why doctors often prescribe tamoxifen for years after initial breast cancer treatment.
The price that these women pay for their increased chance of survival is worsening of their body composition, however. [Breast Cancer Res Treat. 2012 Oct;135(3):663-80.] Their lean body mass – or in other words their muscle mass – reduces and their body fat increases. Strength training can counteract this effect though.
Study
In the study one group of 70 women aged between 70 and 80 took 60 mg raloxifene daily. Another group of 73 women were given a placebo.
Results
Raloxifene did not boost the women's muscle strength, but it did improve some memory functions. [Menopause. 2010 Mar;17(2):309-14.]
Conclusion
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