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03.10.2019


Phosphatidylcholine, a choline analog in eggs and meat, protects against dementia

Phosphatidylcholine, a choline analog in eggs and meat, protects against dementia
Two days ago we wrote about an animal study in which supplementation with choline protected mice against Alzheimer's. According to an epidemiological study that Finnish epidemiologists published in the American Journal of Clinical Nutrition, phosphatidylcholine, a form of choline in eggs and meat, has the same effect in humans.

Study
The researchers followed 2497 Finnish men for approximately 22 years. In 1984-1989, when the study began, the men were 42-60 years old. When the study ended, doctors had diagnosed dementia in 337 men.

The average study participant consumed 431 milligrams of choline daily. 188 milligrams of this compound were in the form of phosphatidylcholine.


Phosphatidylcholine, a choline analog in eggs and meat, protects against dementia



Dairy, meat and eggs provided 27, 24 and 18 percent of the choline respectively. Eggs and meat were the main sources of phosphatidylcholine, and provided 39 and 37 percent of the phosphatidylcholine in the diet, respectively.

Results
There was no association between the intake of choline and the risk of dementia. Conversely, phosphatidylcholine intake was associated with dementia: the group with the highest phosphatidylcholine intake was 28 percent less likely to develop dementia than the men with the lowest intake.


Phosphatidylcholine, a choline analog in eggs and meat, protects against dementia

Phosphatidylcholine, a choline analog in eggs and meat, protects against dementia



Four years after the study began, the researchers measured the cognitive ability of 482 study participants.

On the verbal fluency test, in which people have to name as many words as possible in a certain category in a short period of time, and the trail making test, in which test subjects have to connect a number of points in a logical manner in the shortest time possible, the men who consumed relatively much phosphatidylcholine scored better than the men with relatively low phosphatidylcholine intake.


Phosphatidylcholine, a choline analog in eggs and meat, protects against dementia

Phosphatidylcholine, a choline analog in eggs and meat, protects against dementia



Conclusion
"Higher phosphatidylcholine intake was associated with lower risk of incident dementia and better cognitive performance in men in eastern Finland", summarize the researchers.

"However, this is just one observational study, and we need further research before any definitive conclusions can be drawn", first author Maija Ylilauri adds in a press release. [sciencedaily.com August 6, 2019]

Source:
Am J Clin Nutr. 2019 Jul 30. pii: nqz148. doi: 10.1093/ajcn/nqz148. [Epub ahead of print].

More:
Increase your daily intake of choline, reduce your chance of Alzheimer's 01.10.2019

Archives:
Choline & Choline Analogues
Alzheimer's & Dementia
Cerebrogenics


Ketogenic diet may help prevent dementia Vitamin B6 helps over 60s stay mentally fit More chance of depression and dementia in old people with low zinc levels

Ketogenic diet may help prevent dementia
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Vitamin B6 helps over 60s stay mentally fit
Nutritionists at the University of Ulster in Northern Ireland published a study in Nutrients.

More chance of depression and dementia in old people with low zinc levels
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