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18.01.2018


These two phytochemicals in your diet make melatonin more effective

Melatonin, the hormone that is released during the first stages of healthy sleep, is a very interesting substance. Studies suggest that melatonin has anti-estrogenic, fat-reducing, muscle-building and life-prolonging effects. An Indian biochemist has discovered seems that those effects of melatonin may become stronger if you ingest a relatively large amount of caffeic acid and quercetin, for example through a diet with a lot of vegetables and fruit.

Study
Snehasis Jana of the Trivedi Science Research Laboratory in Bhopal, India wanted to know if there was an interaction between melatonin on the one hand and caffeic acid and quercetin on the other.


These two phytochemicals in your diet make melatonin more effective


All three substances - and analogues thereof - are present in plant foods.



Results
When Jana put melatonin with liver cells in a test tube, he noticed that both caffeic acid and quercetin were limiting the breakdown of melatonin.


These two phytochemicals in your diet make melatonin more effective


In the liver the enzyme CYP1A neutralises melatonin. Caffeic acid and quercetin inhibit that enzyme.

Then Jana administered orally melatonin to rats. The dose was 5 milligrams per kilogram of body weight. The human equivalent of that dose is in the size of several tens of milligrams. In the EU supplement companies are not allowed to sell products with such quantities.



Some rats also received caffeic acid, quercetin or a combination of these two substances. The human equivalent of the doses used corresponds to the amounts that a normal person can consume through vegetables, fruit, herbs and supplements. Jana measured the concentration of melatonin in the rats' blood.


These two phytochemicals in your diet make melatonin more effective


These two phytochemicals in your diet make melatonin more effective


Conclusion
The area under the curve [AUC] indicates the quantities in which a substance has circulated in the body after administration. The figure above shows that the combination of quercetin and caffeic acid more than doubled melatonin's AUC.

Source:
Eur J Drug Metab Pharmacokinet. 2017 Oct;42(5):781-91.

More:
How melatonin makes men more masculine, and protects women against cancer 21.12.2017
A year on melatonin: a couple of kilos less fat and a couple of kilos more lean body mass 04.11.2015
Animal study: combination of melatonin and exercise protects against Alzheimer's 22.07.2014

Archives:
Melatonin
Quercetin


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