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27.04.2019


Animal study: probiotic Lactobacillus casei CRL431 inhibits metastatic breast cancer

Animal study: probiotic Lactobacillus casei CRL431 inhibits metastatic breast cancer
If women with a metastatic form of breast cancer use supplements or functional foods with the probiotic bacterium Lactobacillus casei CRL431, their perspectives improve. This is suggested by an animal study that researchers from the Argentinian Centro de Referencia para Lactobacilos published in the Journal of Functional Foods.

Study
The researchers injected mice with 4T1 breast cancer cells, and waited 2-3 weeks for the tumors to grow. Then they removed the tumors.

4T1 cells resemble aggressive human breast cancer cells. When those cancer types are discovered, they have often already spread throughout the body. Oncologists remove the tumors with surgery and try to fight the remaining cancer cells with medication and radiation. This usually slows down the course of the disease, but a cure is often not possible. The animal study was intended to simulate this condition.

About forty days after the researchers surgically removed the tumors, they examined the apperance of tumors appeared in the lungs of the mice. Some animals died within that time.

The researchers gave half of the mice regular milk, and the other half milk with Lactobacillus casei CRL431, a probiotic bacterium that has been on the market for years. According to previously published studies, Lactobacillus casei CRL431 activates the immune system.

The immune system is the most important line of defense against cancer. Immune cells kill cancer cells. The researchers hoped that administration of Lactobacillus casei CRL431 could delay the course of the disease.


Animal study: probiotic Lactobacillus casei CRL431 inhibits metastatic breast cancer



Results
Supplementation with Lactobacillus casei CRL431 reduced the risk of death and reduced the amount of cancr cells in the lungs of the mice.


Animal study: probiotic Lactobacillus casei CRL431 inhibits metastatic breast cancer



Mechanism
See below how Lactobacillus casei CRL431 inhibited cancer metastasis. The probiotic increased the number of CD4+ and CD4+CD8+ immune cells in the blood of the mice. These types of immune cells play an important role in the body's defense against cancer.


Animal study: probiotic Lactobacillus casei CRL431 inhibits metastatic breast cancer



Conclusion
"The results obtained in this study show the potential of milk fermented with the probiotic strain Lactobacillus casei CRL431 to accompany the treatments after primary breast tumour surgery", write the researchers.

"The importance of the host immune response against metastasis was observed and the results obtained suggest that modulation of some immune populations in the lungs by milk fermented with Lactobacillus casei CRL431 could be a strategy to fight against tumour cells locally in the metastatic sites."

"However, even though the benefits associated with Lactobacillus casei CRL431 were reported for healthy and immunosuppressed hosts, it will be important to evaluate the efficacy of milk fermented with Lactobacillus casei CRL431 in metastasis models after surgery together with drugs used as conventional treatments."

Source:
Journal of Functional Foods 54 (2019) 263-70.

More:
Probiotics arm immune system against cancer cells and germs 13.04.2019
Kefir inhibits tumor growth: animal study 18.09.2018
Older than 55? Yakult keeps your immune system strong 15.09.2018

Archives:
Cancer Prevention & Survival
Breast Cancer
Probiotics


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