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09.09.2018


Lab tests: 24 higenamine supplements

Lab tests: 24 higenamine supplements
Lab tests: 24 higenamine supplements
If you use weight loss supplements, energy pills or pre-workout formulas with higenamine, then you really do not know how much of this substance you're putting into you body. Maybe nothing at all, maybe more than 100 milligrams. This is evident from an analysis of 24 supplements by Pieter Cohen of the University of Harvard and researchers from the Dutch RIVM.

Higenamine
Higenamine is a stimulant, which according to in vitro research interacts with the adrenergic beta-2 receptor - just like terbutaline and salbutamol. In theory, administration of higenamine could lead to a shift in body composition towards less fat and more muscles.

We do not know whether this is the case. It has never been studied. That did not stop the supplement industry from putting higenamine in supplements. Officially these supplements contain plant extracts with higenamine, but the higenamine in supplements is almost always of synthetic origin.

Higenamine is on the doping list. Athletes who use supplements with higenamine can therefore get into trouble. [usada.org March 23, 2018] [usada.org August 16, 2017]

We don't know if higenamine is dangerous. Cohen managed to get his hands on Chinese human studies, in which higenamine in people increased blood pressure and accelerated the heart rate, but in these studies researchers administered higenamine in small quantities by slow drip infusion. It's hard to tell form these studies what the effect of oral dosages would be.


Lab tests: 24 higenamine supplements



Results
The amount of active substance in the supplements varied considerably. In some supplements, the researchers found nothing or virtually nothing, but they also analyzed a supplement that contained more than 100 milligrams of higenamine per recommended daily maximum dose.

The products' labels were inaccurate. They often didn't mention dosages, and if they did they turned out to be wrong.

The table below is also simplified. The integral version can be found here.


Name

By

On label

Milligrams of higenamine / maximum recommended dosage

Adrenal Pump

Total Body Nutrition

Norcoclaurine HCl (higenamine HCl)

57

Beta-Stim

Ronnie Coleman Signature Series

Higenamine

69

Burn-HC

VMI Sports

Higenamine (norcoclaurine) [20 mg]

29

Defcon-1 Second Strike

Platinum Labs

Higenamine [50 mg]

Nothing

Diablo

ANS Performance

Higenamine HCl

44

DyNO

RSP Nutrition

Higenamine hydrochloride

27

Gnar Pump

Brosupps

Higenamine

Nothing

Higenamine

Powder City

Higenamine HCl [20 mg]

7.4

High Definition

MBI Performance

Higenamine HCl

110

HyperMax

PerforMax Labs

Higenamine HCl

Nothing

iBurn2

M4 Nutrition

Higenamine

6.8

Liporidex Max

Nuretix Research

Norcoclaurine HCl (higenamine)

6.1

Liporidex Plus

Nuretix Research

Norcoclaurine HCl (higenamine)

5.9

LipoRush DS2

NDS Nutrition

Higenamine HCl

41

N.O. Vate

Applied Nutriceuticals

Norcoclaurine HCl

25

OxyShred

EHP Labs

Higenamine HCl

70

Prostun-Advanced Thermogenic

HD Labs

Higenamine HCl [10 mg]

39

Pyroxamine

Myokem

Nelumbo nucifera (std. to higenamine)

89

Razor8

AllMax Nutrition

Higenamine HCl (norcoclaurine) [45 mg]

62

Ritual

ANS Performance

Higenamine HCl (norcoclaurine)

14

Stim Shot

LeCheek Nutrition

Higenamine HCl

88

ThermoVate

Applied Nutriceuticals

Norcoclaurine

18

Uplift

NLA for Her

Norcoclaurine

3



Conclusion
"We're urging competitive and amateur athletes, as well as general consumers, to think twice before consuming a product that contains higenamine", says co-author John Travis in a press release. [sciencedaily.com September 6, 2018]

"Beyond the doping risk for athletes, some of these products contain extremely high doses of a stimulant with unknown safety and potential cardiovascular risks when consumed. What we've learned from the study is that there is often no way for a consumer to know how much higenamine is actually in the product they are taking."

Source:
Clin Toxicol (Phila). 2018 Sep 6:1-6. doi: 10.1080/15563650.2018.1497171. [Epub ahead of print].

More:
Grey market epitalon products are genuine 20.01.2017
Corticosteroids and antihistamines found in Mayhem 25.11.2014
DMBA: unknown amphetamine-like substance found in 13 supplements 14.11.2014

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