Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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14.06.2016 |
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If leucine isn't stimulating muscle growth, try combining it with glycine
All bodybuilders and fitness fanatics know leucine. Many studies have shown that it stimulates anabolic processes in muscle cells, but others suggest that leucine doesn't always work. Aging, long periods of inactivity and other conditions under which the body produces large amounts of inflammatory factors and oxidants can eliminate the anabolic effect of leucine. Under these circumstances, adding glycine as a supplement may offer a solution, Australian physiologists discovered.
Leucine & glycine
Glycine is a non-essential amino acid that sports scientists generally don't pay much attention to, but according to recent studies it does actually have some interesting characteristics. Some basic research studies suggest that glycine rejuvenates old cells and protects muscle tissue against breakdown caused by cancer, probably because glycine blocks inflammatory factors. For other posts on glycine click here.
Study
Some of the lab animals were given the amino acid alanine [ALA] a few hours before being given lipopolysaccharide. Alanine has an anti-inflammatory effect. Another group of animals were given glycine.
Several hours after administration the researchers gave the mice leucine, and then looked at the effects this had on the animals' muscle tissue.
Results
CON = mice given no lipopolysaccharide, no alanine and no glycine.
Lipopolysaccharide inhibited the key anabolic molecule mTOR, but the leucine-glycine combination neutralised this effect.
Conclusion
"Further work is required to elucidate the key signaling pathways responsible for the beneficial effect of glycine."
"The identification of glycine as a novel nutritional intervention to restore the anabolic sensitivity of skeletal muscle to leucine has potential implications for a range of muscle wasting conditions."
Dosage
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