Losing body fat with Pycnogenol?
It's not impossible that supplementation with Pycnogenol enhances fat loss. This is suggested by a Chinese animal study, that has been published in the Journal of Diabetes Research. According to that study, Pycnogenol changes the way fat cells function. It makes them dump their contents more easily into the blood stream, and lets them use a little more energy themselves.
The researchers gave mice high-calorie food [HCD] for 8 weeks. Mice therefore become fat. A control group received standard feed [ND] during that period and thus remained slim.
A group of mice received a relatively low dose of Pycnogenol [LoPYC + HCD] every day, in addition to high-calorie feed. Had the mice been adult people, they would have received about 300 milligrams of Pycnogenol every day.
Another group of mice received a relatively high dose of Pycnogenol [HiPYC + HCD]. Had these mice been adult humans, they would have taken about one gram of Pycnogenol a day.
The researchers used extracts from the Swiss Pycnogenol manufacturer Horphag. [pycnogenol.com] However, the researchers were not paid by Horphag; they received their funding from the Chinese government.
Supplementation with both the low [LoPYC + HCD] and the high dose of Pycnogenol [HiPYC + HCD] virtually eliminated the fattening effect of the high calorie feed [HCD] and inhibited the growth of adipose tissues.
In white adipocytes, Pycnogenol inhibited the PLN1 gene, which is involved in the storage of fat. Simultaneously, Pycnogenol activates the 'fat sensors' PPAR-alpha and gamma. More strikingly, Pycnogenol increased the concentration of hormone-sensitive lipase [HSL] in the white fat cells. That enzyme cuts fatty acids from triglycerides, [lipolysis] which makes adipocytes dump free fatty acids into the bloodstream. The body can use these free fatty acids as fuel.
Pycnogenol also maintained the concentration of PGC-1 alpha in the fat cells. PGC-1-alpha stimulates cells to make mitochondria. The more mitochondria cells have, the more nutrients they can convert into energy.
All these processes are probably set in motion because Pycnogenol activates the enzyme cAMP-dependent protein kinase [PKA].
"In conclusion, our data demonstrate that Pycnogenol can effectively reduce body weight and body fat deposition", write the researchers. "This finding suggests that Pycnogenol administration may be a novel strategy for preventing and treating obesity and associated metabolic diseases."
The discovered mechanism suggests that the slimming effect of Pycnogenol becomes stronger in combination with beta-agonists. After alle, PKA increases beta-adrenergic activity. The fact that phenols [the active substances in Pycnogenol are phenols] strengthen the action of beta-agonists has been shown in studies before.
J Diabetes Res. 2018 Jan 17;2018:9713259.
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Supplementation & Fat Loss