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19.04.2014


1973 animal study: DMAE extends lifespan

Dimethylaminoethanol (DMAE)
If you give aging, but not too old, healthy lab mice a little DMAE every day, they live 50 percent longer than lab mice that are not given DMAE. A study published in 1973 in Experimental Gerontology shows this.

Study
Initially Richard Hochschild experimented with another compound of which he suspected that it might have a life-extending effect: dimethylaminoethyl p-chlorophenoxyacetate or meclofenoxate [structural formula shown here]. [Exp Gerontol. 1973 Aug;8(4):177-83.]

Meclofenoxate
Meclofenoxate however disintegrates in the body into several other compounds, one of which is dimethylamino-ethanol [DMAE].

This caused Hochschild to wonder whether the life-extending effects of meclofenoxate that he'd observed in his animal studies were actually the work of DMAE, and he decided to conduct an experiment in which he added DMAE to the drinking water of male J/A mice. These mice, for lab mice at least, live to be quite old. At the start of Hochschild's study the animals were all older than 600 days.

Hochschild used the acetamidobenzoate salt of DMAE. In terms of pure DMAE the human equivalent of the dose the mice were given would be 7 mg DMAE per kg bodyweight per day.

Results
The curves in the figure below show how long the mice in the experimental group and in the control group survived. The last mouse in the control group died after 273 days. It was another 99 days after this before the last mouse in the DMAE group died.

The mice in the control group lived for an average of another 57 days; the mice in the DMAE group lived for an average of another 85 days.


If you give aging, but not too old, healthy lab mice a little DMAE every day, they live 50 percent longer than lab mice that are not given DMAE. A study published in 1973 in Experimental Gerontology suggests this.


If you give aging, but not too old, healthy lab mice a little DMAE every day, they live 50 percent longer than lab mice that are not given DMAE. A study published in 1973 in Experimental Gerontology suggests this.


Hochschild wrote that he suspected that DMAE is a superior raw material for phosphatidylcholine, which cells use as a building block for their membranes. Cells that are given DMAE age less quickly.

Conclusion
"It is interesting that sizeable life span extensions were obtained in the present experiment even though drug administration was started late in the animals' life", writes Hochschild. "The drug treatment began well past the mean expected life span for this strain, listed by Green to be 490 days. [...] "It can be concluded that life span may be influenced pharmacologically well into old age."

Source:
Exp Gerontol. 1973 Aug;8(4):185-91.

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