Combination of fish oil and curcumin activates anabolism in inactive muscles
If you do not use your muscles, your body breaks them down. The elderly, the seriously ill, injured athletes and astronauts know all about it. Fish oil and curcumin supplementation can inhibit or maybe even stop this breakdown, researchers at Texas A&M University discovered. They did animal studies for the American space organization NASA.
For 17 days, the researchers gave mice feed with large amounts of fish oil and curcumin [HU + FOC]. On Day 10, the researchers made sure that the mice could no longer use their hind leg, and on Day 17, they looked at what had happened to the soleus muscle of the inactive hind leg.
Mice in a control group, which could not use their hind legs either, had eaten food without additives [HU]. Mice in another control group were free of movement restrictions, and had received food without additives [CON].
Supplementation prevented muscle decay.
The molecular anabolic signalling machinery stopped working in the inactive muscles. The combination of fish oil and curcumin prevented this.
You can see above how fish oil supplementation and curcumin protected anabolism. Supplementation increased the activity of heat shock protein-70 [HSP70]. Heat shock proteins are the styrofoam of the cell. When the cell is under stress, heat shock proteins form complexes with the cell's crucial molecules that cannot be damaged easily.
The doses used by the researchers are astronomically high. That's what you get when you work for NASA. If the mice had been people weighing 80 kg, they would have received 60 grams of fish oil and 12 grams of curcumin daily.
"That won't work." We haven't uploaded this post yet, but we can already hear you grumbling. Maybe you are right, but maybe not.
We will continue soon.
Nutr Res. 2019 Jan 7. pii: S0271-5317(18)31123-0. doi: 10.1016/j.nutres.2018.12.013. [Epub ahead of print].
More muscles in old age thanks to curcumin supplementation 12.03.2019
MRI captures anticatabolic effect of curcumin 01.11.2014
Curcumin helps damaged muscle recover faster 13.06.2011
Curcumin isn't anticatabolic at all – it's anabolic 07.06.2011