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08.12.2015


Citrulline increases muscle mass and reduces fat mass by blocking the aging process

If you are heading towards old age, a daily dose of the alpha amino acid L-citrulline may help reduce the amount of fat and increase the amount of muscle you have. Researchers at the Sorbonne in France suggest this in an animal study they published in the Journal of Nutrition. Citrulline has a positive effect on body composition because it blocks aging processes at a fundamental level.

Study
Citrulline increases muscle mass and reduces fat mass by blocking the aging process
The researchers did an experiment with rats aged 20 weeks, 'young elderly'. They gave the animals 1 g citrulline per kg bodyweight [structural formula on the right] every day for 12 weeks, or 1 g of a mixture of other non-essential amino acids. The human equivalent of the dose used would be 0.16 g per kg bodyweight.

Results
At the end of the supplementation period the rats in both groups weighed the same, but their body composition was different. The animals that had been given citrulline had 13 percent less fat and 9 percent more lean body mass than the animals that had been given the mix of non-essential amino acids.


Citrulline increases muscle mass and reduces fat mass by blocking the aging process


Citrulline increases muscle mass and reduces fat mass by blocking the aging process


The figure above shows that the rats in the citrulline group had 14-48 percent more muscle mass after the supplementation than the animals in the other group.

The citrulline supplementation had no relevant effect on the anabolic signal molecule mTOR, but cells did manufacture more proteins such as TFAM as a result of the supplementation. These proteins enable cells to build up and repair more mitochondria. Mitochondria convert nutrients into energy.

NEAA = rats that were given non-essential amino acid mix in their food; CIT = rats that were given citrulline.


Citrulline increases muscle mass and reduces fat mass by blocking the aging process


This suggests that citrulline delays aging. During the process of aging the number of mitochondria in all cells decreases and their quality declines too. The result is that tissue dies off as the energy supply decreases and the mitochondria start to produce more and more aggressive oxygenated radicals.

Citrulline seems to reduce this last aspect of aging. At least, the researchers found less oxidised LDL in the rats' blood. Oxidised cholesterol is bad news for the blood vessels, so this effect of citrulline is also positive.

Conclusion
"Citrulline treatment in male aged rats favourably modulates body composition and protects against lipid oxidation and, thus, emerges as an interesting candidate to help prevent the aging process", the researchers concluded. "Our results provide a strong rationale for promoting trials with citrulline in humans."



The study was financed by the French Association Against Myopathies. The first author and two other co-authors of the study work for the French company Citrage [citrage.com]. Citrage sells citrulline supplements designed to maintain muscle strength.

Source:
J Nutr. 2015 Jul;145(7):1429-37.

More:
Build muscles but eat little protein? Use L-citrulline 23.07.2014
L-Citrulline changes apple into pear 10.07.2014
L-Citrulline helps you hold on to muscle mass during a weight-loss diet 04.10.2009

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