Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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17.02.2018 |
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Betaine forces fat cells to eat themselves
Supplementation with a hefty dose of betaine inhibits the growth of fat cells. According to an animal study that researchers from Sichuan Agricultural University published in Nutrients, betaine allows the body to build up more lean body mass while inhbiting the growth less fat mass. This happens when the body receives more energy than it burns, but also when caloric intake and burning are perfectly in balance.
Study
Results
In mice that received normal feed, supplementation with betaine [HC-bet] had a slimming effect. In mice that got more energy in their food than they burned [H-BET], too. It seems that betaine caused the animals to use the excess energy to increase their lean body mass instead of their fat mass.
In the animals that were fattened, betaine kept the concentration of triglycerides [TG] and the 'bad cholesterol' LDL low.
When the researchers experimented with 3T3-L1 fat cells in in vitro, they saw that betaine inhibited their growth. Betaine increased the activity of the growth enzymes cyclin-D and -E, and activated the growth inhibitory genes P53 and P21. [The latter two genes also inhibit the growth of cancer cells, and stimulate the production of mitochondria in numerous cell types.]
In the fat cells, betaine reduced the activity of enzymes that store calories as fat. In the fat cells the activity of enzymes that burn fat, however, went up. Betaine is therefore a 'fat browner', just like curcumin and green tea. Maybe you could stack betaine with those substances...
Conclusion
"Following betaine supplementation, high fat diet-fed mice displayed a significant decrease in plasma lipid and lipoprotein levels, such as triglycerides and LDL."
"Additionally, the authors found [...] reduced expression of some genes promoted lipid synthesis in white adipose tissue of high fat diet-fed mice."
"Therefore, dietary betaine supplementation can be considered as a possible therapeutic approach for obesity and hyperglycemia."
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