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02.11.2013


The anabolic effect of combining salbutamol with L-dopa

Ten years ago neurologists at the University of Arkansas published in Clinical Neuropharmacology the results of a small study, which may or may not be of interest to our dear readers. Nor do we know for sure whether salbutamol and L-dopa  the combination that the neurologists tested in the study  is completely safe. What we do know is that the anabolic effects that the researchers observed are remarkable.
Ten years ago neurologists at the University of Arkansas published in Clinical Neuropharmacology the results of a small study, which may or may not be of interest to our dear readers. Nor do we know for sure whether salbutamol and L-dopa the combination that the neurologists tested in the study is completely safe. What we do know is that the anabolic effects that the researchers observed are remarkable.

The eight people who served as subjects for the neurologists' experiment all suffered from Parkinson's and had an average age of 59. They were already taking L-dopa, an amino acid that boosts the production of dopamine in the brain. The body's production of dopamine declines rapidly with the onset of Parkinson's and as a result brain cells lose their function. L-Dopa supplementation reduces the symptoms in the first stage of the disease.

The average L-dopa dose of the subjects was 481 mg per day.

Cells absorb more L-dopa, and therefore also produce more dopamine, when they are exposed to adreno-beta-2-agonists. [Am J Physiol Renal Physiol. 2000 Jul;279(1):F77-83.] Animal studies have shown that adreno-beta-2-agonists improve the brain's uptake of L-dopa. [Eur J Pharmacol. 1992 May 14;215(2-3):245-51.]


Ten years ago neurologists at the University of Arkansas published in Clinical Neuropharmacology the results of a small study, which may or may not be of interest to our dear readers. Nor do we know for sure whether salbutamol and L-dopa  the combination that the neurologists tested in the study  is completely safe. What we do know is that the anabolic effects that the researchers observed are remarkable. Ten years ago neurologists at the University of Arkansas published in Clinical Neuropharmacology the results of a small study, which may or may not be of interest to our dear readers. Nor do we know for sure whether salbutamol and L-dopa  the combination that the neurologists tested in the study  is completely safe. What we do know is that the anabolic effects that the researchers observed are remarkable.

Salbutamol

L-Dopa


That's why the researchers wanted to try the combination of salbutamol, a mild adreno-beta-2-agonist, and L-dopa, to see what effect it would have on their patients. They gave their subjects 4 oral doses of 4 mg salbutamol daily.

In one sixty-year-old patient the salbutamol/L-dopa combination caused headache, restlessness and trembling. She stopped taking the combo after two weeks. The other subjects continued for 14 weeks. During this period they also did strength training twice a week.

The table below shows that the subjects' maximal strength increased by a modest amount and that their body composition changed considerably. While there was no change in the subjects' bodyweight, their lean body mass increased by 7.7 kg.

Ooh la la.


Ten years ago neurologists at the University of Arkansas published in Clinical Neuropharmacology the results of a small study, which may or may not be of interest to our dear readers. Nor do we know for sure whether salbutamol and L-dopa  the combination that the neurologists tested in the study  is completely safe. What we do know is that the anabolic effects that the researchers observed are remarkable.


Don't take any notice of the weight that the subjects lifted with the chest press. No doubt there's an editorial error there.

In half of the patients the addition of salbutamol to the L-dopa medication reduced the symptoms of the Parkinson's.

The researchers emphasise that they don't know whether the combination they tested is safe.

"The observed significant increase in the mean heart rate, seen in ten percent of patients using salbutamol, and the isolated case reports of cardiac arrhythmias and angina underscore the need for careful cardiac evaluation when use of salbutamol is considered", they write. "The central nervous system side effects include enhanced physiologic tremor (twenty percent), insomnia, dizziness, drowsiness, restlessness, irritability, nervousness, visual hallucinations, and headache."

Source:
Clin Neuropharmacol. 2003 Jul-Aug;26(4):207-12.

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