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07.05.2016


Animal study: 120 mg clove extract daily boosts testosterone level

Animal study: 120 mg clove daily boosts testosterone level
If you don't take too much of it, clove scientific name Syzygium aromaticum boosts your testosterone level. At least, that's what researchers at Banaras Hindu University in India suspect after demonstrating the testosterone-enhancing effect of Syzygium aromaticum in lab animals. The results of their study have bene published in Andrologia. When we read it we came across a couple of things that we thought our readers would definitely find interesting.

Syzygium aromaticum
Syzygium aromaticum contains among other things eugenol, eugenyl-acetate, carvacrol, thymol, cinnamaldehyde, chavicol, acetyl-salicylate, humulenes, dehydrodieugenol, transconiferyl-aldehyde, beta-caryophyllen and alpha-copaen. It is not known which of these substances is actually responsible for the testosterone-boosting effect.

The researchers made their extracts themselves, and how they did this is shown below.


Animal study: 120 mg clove daily boosts testosterone level



Study
The researchers gave male mice a daily dose of 15, 30 or 60 mg extract per kg bodyweight for five weeks. They dissolved the extract in water and gave it to the mice orally. The human equivalent of the doses used based on a man weighing 80 kg would be about 120, 240, or 480 mg extract per day.

For ergonauts who want to use just ground cloves, the human equivalent of the doses used would be 16.7 times higher.

Results
The lowest dose of Syzygium aromaticum that the researchers tested boosted the synthesis of testosterone by more than a quarter, as the figure below shows. Higher doses had the opposite effect.


Animal study: 120 mg clove daily boosts testosterone level



The same figure also reveals how Syzygium aromaticum gets the testes to produce more testosterone: the extract boosts the activity of the enzymes 3-beta and 17-HSD, both of which play a key role in the biosynthesis of testosterone.

By the way, the low dose supplementation also boosted the lab animals' fertility. And again, the higher doses had a negative effect on fertility.

Conclusion
"In conclusion, the data of present study indicate the biphasic nature of Syzygium aromaticum flower buds on reproductive physiology of male mice", the researchers summarised. "The lower (15 mg) dose is stimulatory, while higher (30 and 60 mg) doses exert adverse effects on functional physiology of male reproductive organs and fertility."

"Further, our results also suggest that lower dose of Syzygium aromaticum is androgenic in nature and may have a viable future as an indigenous sexual rejuvenator."

Warning
It is not clear how safe long-term use of high quantities of Syzygium aromaticum is. What is known is that high doses can cause damage to teeth and gums. If you still want to experiment with clove, take it in capsule form and don't do it for too long. And read up on the potential side effects.

Source:
Andrologia. 2016 Nov;48(9):923-32.

More:
Just a little clove for more testosterone 05.05.2009

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