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Ergo-Log

12.06.2023


Fifty scientists after a decade of research: taurine may be an anti-aging drug

CNN, the news station for English-speaking and highly educated people who know exactly where this world should go, puts the supplement geeks back in their place. "Is taurine the ellxir of life?", CNN headlines on its website. "Maybe, if you're a worm, mouse or monkey."


Fifty scientists after a decade of research: taurine may be an anti-aging drug


And this with only 1 typo in the headline. And with beautiful footage of fish oil capsules underneath. How appropriate.

This, boys and girls, is quality journalism. No wonder more and more people are watching CNN day-in-day-out.

The research that CNN so cleverly puts in place appeared in a silly periodical called Science. Moreover, the study was not funded by Pfizer. Then, as a journalist of a medium for highly educated people like CNN, you know enough.

We, the industrious and deplorable compilers of this free web magazine, are not as intelligent as CNN's clever copywriters. So we read the study that Parminder Singh, a researcher from the National Institute of Immunology in New Delhi, India, and his colleagues published in the first week of June 2023.


Fifty scientists after a decade of research: taurine may be an anti-aging drug


Taurine
The Science article is a compilation of several studies, conducted by about fifty scientists, working in several laboratories all over the world. The project took a total of ten years to complete.

The researchers determined, among other things, how much taurine is present in people's blood, and saw that this concentration decreases as people get older. Taurine is found in animal products, especially fish and meat. Omnivores consume several tens to several hundred milligrams of taurine daily, but the human body also produces taurine by metabolizing cysteine.


Fifty scientists after a decade of research: taurine may be an anti-aging drug


There is approximately one gram of taurine in one kilogram of human tissue. The body uses taurine to get rid of excess cholesterol and to protect cells against damage, for example from unhealthy high concentrations of glucose.

Live longer
To determine whether taurine indeed has a life-extending effect, the researchers gave 14-month-old C57Bl/6J lab mice - middle-aged, so to speak - a hefty dose of taurine every day for the rest of their lives.

If the mice had been humans, they would have received one gram of taurine per 10 kilograms of body weight every day. Some individuals respond well to it, others will experience side effects. There is a group of people who suffer from insomnia due to supplementation with taurine.

Either way, taurine supplementation extended the overall lifespan of the mice by 10-12 percent.


Fifty scientists after a decade of research: taurine may be an anti-aging drug


Stronger & healthier
In another series of animal experiments, the researchers gave female mice every day from the time they were 14 months old no taurine [in the figures below: white], a relatively low dose [light blue] or a relatively high dose of taurine [dark blue]. If the mice had been humans, they would have received zero, half or a whole gram of taurine per 10 kilograms of body weight every day.

When the mice were 24 months old, the researchers studied the animals. They saw that in the animals that had been given taurine, fat reserves were smaller, bones and muscles were stronger, agility and body coordination were better, and fear and anxiety were less.


Fifty scientists after a decade of research: taurine may be an anti-aging drug

Fifty scientists after a decade of research: taurine may be an anti-aging drug


In addition, just as the researchers had expected, taurine supplementation improved glucose and insulin metabolism.

The researchers also looked at the effects at the molecular level. After supplementing with taurine in older lab animals, they saw a decrease in markers that indicate free radical activity, DNA damage, aging [such as senescence-associated beta-galactosidase] - and also registered less activity of inflammatory proteins such as TNF-alpha and interleukin-17-alpha.

Apparently supplementation with taurine not only extends the life span of the test animals, but also their health span. The researchers did similar experiments with rhesus monkeys. The results pointed in the same direction as those of the mouse experiments.

Conclusion
"Taurine abundance decreases during aging", summarize the researchers. "A reversal of this decline through taurine supplementation increases health span and life span in mice and worms and health span in monkeys. This identifies taurine deficiency as a driver of aging in these species."

"To test whether taurine deficiency is a driver of aging in humans as well, long-term, well-controlled taurine supplementation trials that measure health span and life span as outcomes are required."

Source:
Science. 2023 Jun 9;380(6649):eabn9257.

More:
Taurine, a supplement for diabetics 18.07.2022
Daily dose of 1500 mg of taurine slows aging 05.07.2022
Taurine's mechanism of action revealed 21.05.2022

Archives:
Longevity
Taurine


AKG cycle makes you up to 8 years younger Getting enough vitamin B6 will make you live longer Circulating omega-3 fatty acids from fish reduce mortality risk

AKG cycle makes you up to 8 years younger
A real human study, although conducted without a control group.

Getting enough vitamin B6 will make you live longer
If there is an adequate amount of vitamin B6 circulating in your body, you may live longer than if this amount is small. Epidemiology.

Circulating omega-3 fatty acids from fish reduce mortality risk
Meta-study. Epidemiology.